Institut de Biologie Valrose
Institut de Pharmacologie Moléculaire et Cellulaire
Centre Méditerranéen de Médecine Moléculaire
Institute for Research on Cancer and Aging of Nice
Institut Sophia Agrobiotech
Sophia Antipolis-Méditerranéen Research Centre
Our goal for the next eight years is to reinforce our leadership on model Signaling Pathways (SP) and processes studied by SIGNALIFE partners, gain a deeper understanding of their organization and function, identify new frontiers and concepts, altogether contributing to the building of an innovative campus of excellence on signaling.
5 Research Axes
The SIGNALIFE project is organized into 5 main axes, building on existing research expertise and collaborative work from partners to address specific questions, as follows:
1 ‘Cellular architecture of signaling pathways’:
Leaders: Antonny, Fürthauer, Lemichez, Thérond
We will explore the structure, organization, compartmentalization and function of major model SP studied by partners. Genetic, proteomic and biochemical screens will be used for new component discovery.
Participants: Arkowitz, Besse, Cormont, Franco, Hueber, Luton, Martin, Noselli, Poirié, Tanti, Van Obberghen-Schilling
2 ‘Plasticity and Signaling’:
Leaders: Collombat, Abad, Dani, Nahon
Using a range of model systems, we will explore the molecular mechanisms underlying cell plasticity through biological SP involved in stem and reprogrammed cells.
Participants: Braendle, Chaboissier, Gilson, Frendo, Noselli, Studer, Rassoulzadegan, Robichon
3 ‘Stress Signaling’:
Leaders: Léopold, Ballotti, Keller, Magnaldo
Cells and organisms respond to various internal and external stresses. We will explore the dynamics of a range of stress signals and their impact on cells, tissues and organisms through modifications of various SP.
Participants: Abad, Arkowitz, Anjuere, Barbry, Braendle, Braud, Cristofari, Delaunay, Féral, Gilson, Glaichenhaus, Frendo, Lambeau, Lemichez, Léopold, Liti, Meneguzzi, Panabières, Poirié, Robichon, Tanti, Schedl, Van Obberghen, Van Obberghen-Schilling
4 ‘Signaling in aging and disease progression’:
Leaders: Glaichenhaus, Ricci, Tanti, Van-Obberghen
We will explore the molecular mechanisms leading to SP dysfunction during aging and in a range of pathologies including cancer, neurological, metabolic and inflammatory disorders.
Participants: Anjuere, Auberger, Ballotti, Barbry, Bardoni, Besse, Braud, Cristofari, Dani, Feral, Gilson, Glaichenhaus, Gual, Hofman, Hueber, Lalli, Lambeau, Leopold, Magnaldo, Marie, Meneguzzi, Schedl, Studer, Tartare-Deckert, Trabucchi, Tran, Van Obberghen-Schilling
5 ‘New principles in signaling and applications’:
Leaders: Poirié, Besse, Gouzé, Descombes
In this transversal axis, we will set up conditions for maximal data/ideas sharing between all participants and develop modeling with the aim of making new hypotheses and concepts leading to innovative projects and large scale cross-platform srceens.
Participants: all 49 group leaders.