Research Institutes


Network for Innovation on Signal Transduction Pathways in Life Sciences

Partner 1


Institut de Biologie Valrose

Partner 2


Institut de Pharmacologie Moléculaire et Cellulaire

Partner 3


Centre Méditerranéen de Médecine Moléculaire

Partner 4


Institute for Research on Cancer and Aging of Nice

Partner 5


Institut Sophia Agrobiotech

Partner 6


Sophia Antipolis-Méditerranéen Research Centre

Our goal for the next eight years is to reinforce our leadership on model Signaling Pathways (SP) and processes studied by SIGNALIFE partners, gain a deeper understanding of their organization and function, identify new frontiers and concepts, altogether contributing to the building of an innovative campus of excellence on signaling.


Research Axes

5 Research Axes

The SIGNALIFE project is organized into 5 main axes, building on existing research expertise and collaborative work from partners to address specific questions, as follows:

1 ‘Cellular architecture of signaling pathways’:
Leaders: Antonny, Fürthauer, Lemichez, Thérond
We will explore the structure, organization, compartmentalization and function of major model SP studied by partners. Genetic, proteomic and biochemical screens will be used for new component discovery.
ParticipantsArkowitz, Besse, Cormont, Franco, Hueber, Luton, Martin, Noselli, Poirié, Tanti, Van Obberghen-Schilling

2 ‘Plasticity and Signaling’:
LeadersCollombat, Abad, Dani, Nahon
Using a range of model systems, we will explore the molecular mechanisms underlying cell plasticity through biological SP involved in stem and reprogrammed cells.
ParticipantsBraendle, Chaboissier, Gilson, Frendo, Noselli, Studer, Rassoulzadegan, Robichon

3 ‘Stress Signaling’:
LeadersLéopold, Ballotti, Keller, Magnaldo
Cells and organisms respond to various internal and external stresses. We will explore the dynamics of a range of stress signals and their impact on cells, tissues and organisms through modifications of various SP.
ParticipantsAbad, Arkowitz, Anjuere, Barbry, Braendle, Braud, Cristofari, Delaunay, Féral, Gilson, Glaichenhaus, Frendo, Lambeau, Lemichez, Léopold, Liti, Meneguzzi, Panabières, Poirié, Robichon, Tanti, Schedl, Van Obberghen, Van Obberghen-Schilling

4 ‘Signaling in aging and disease progression’:
LeadersGlaichenhaus, Ricci, Tanti, Van-Obberghen
We will explore the molecular mechanisms leading to SP dysfunction during aging and in a range of pathologies including cancer, neurological, metabolic and inflammatory disorders.
ParticipantsAnjuere, Auberger, Ballotti, Barbry, Bardoni, Besse, Braud, Cristofari, Dani, Feral, Gilson, Glaichenhaus, Gual, Hofman, Hueber, Lalli, Lambeau, Leopold, Magnaldo, Marie, Meneguzzi, Schedl, Studer, Tartare-Deckert, Trabucchi, Tran, Van Obberghen-Schilling

5 ‘New principles in signaling and applications’:
LeadersPoirié, Besse, Gouzé, Descombes
In this transversal axis, we will set up conditions for maximal data/ideas sharing between all participants and develop modeling with the aim of making new hypotheses and concepts leading to innovative projects and large scale cross-platform srceens.
Participants: all 49 group leaders.

Group Leaders

Group leaders