Abad Pierre – Plant nematode interactionsAbad Pierre Plant nematode interactionsPlant-parasitic nematodes have evolved sophisticated strategies for exploiting plants. These pathogens induce the redifferentiation of plant cells into specialized multinucleate feeding sites. We develop an integrated approach combining plant pathology and plant biotechnology to identify key players involved in signalling pathways of host–parasite molecular dialogue, plant development and immunity.Keywords: Plant, Nematode, Interaction, Development, Immunity
Antonny Bruno – Dynamics of lipid membranes and protein coatsAntonny Bruno Dynamics of lipid membranes and protein coats We study (1) protein coats, which deform membranes into transport vesicles; (2) molecular strings, which tether vesicles at the Golgi; and (3) lipid transporters, which change the membrane composition and hence contribute to the maturation of membrane-bound organelles.Key words: membrane traffic, liposomes, cell biology, biochemistry and biophysics
Arkowitz Robert – Polarized growth in yeastArkowitz Robert Polarized growth in yeastOur primary interest is how cells spatially and temporally regulate their growth. We are examining the mechanisms of polarized growth and cell morphogenesis in both S. cerevisiae and C. albicans, in particular investigating the roles of G-proteins and lipids in these processes.Key words: Polarized growth, morphogenesis, G-protein, lipids, cell shape
Auberger Patrick – Cell Death, Differentiation, Inflammation and CancerAuberger Patrick Cell Death, Differentiation, Inflammation and CancerOur team investigates the deregulation in cell death processes and autophagy in hematopoietic malignancies. We are also developping new alternative therapeutic strategies to circumvent the resistance to conventionnal chemotherapies focusing our interest on leukemia, myelodysplastic syndromes and myeloma.Keywords: Autophagy, Cell Deaths, Hematopoietic Malignancies, Resistance to Chemotherapies, New Anti-cancerous Therapies
Ballotti Robert – Biology and pathology of melanocytic cells: from cutaneous pigmentation to melanomasBallotti Robert Biology and pathology of melanocytic cells: from cutaneous pigmentation to melanomasThe work of our team is focused on the study of the molecular mechanisms involved in melanocyte differentiation and in melanoma development, with special emphasis on MITF, a transcription factor that controls the expression on numerous genes playing a crucial role in melanocyte and melanoma biology.Keywords: Pigmentation, Cancer, therapy, transcription, epigenetic
Barbry Pascal – Physiological Genomics of the EukaryotesBarbry Pascal Physiological Genomics of the EukaryotesRegulatory RNAs in normal and physiopathological function of epithelial tissues. Their roles in respiratory diseases. Technological developments for multi-parametric measurements in different biological models.
Keywords: Gene expression, high throughput sequencing, bioinformatics, epithelium, cancer
Bardoni Barbara – Physiopathology of intellectual disabilityBardoni Barbara Physiopathology of intellectual disability
The purpose of our research is to understand the molecular function of the RNA-binding protein FMRP, whose altered expression is linked to Fragile X syndrome, the most common form of intellectual disability and autism, and FXTAS, a late-onset neurodegenerative disorder.
Keywords: Intellectual disability, autism, neurodegeneration, RNA-binding protein, RNA metabolism
Besse Florence – Post-transcriptional control of axon growth and guidance in DrosophilaBesse Florence Post-transcriptional control of axon growth and guidance in Drosophila
Our group studies the post-transcriptional regulatory mechanisms underlying the response of growing axons to external guidance signals in vivo, in particular the role of intracellular mRNA transport. Various approaches (genetics, live-imaging, biochemistry, bioinformatics) are combined.
Keywords: developmental cell biology, polarized axon growth, RNA transport, genetics, live-imaging
Braendle Christian – Gene-environment interactions in development and evolutionBraendle Christian Gene-environment interactions in development and evolution
We use the nematode Caenorhabditis elegans as a study organism to better understand how development responds to environmental variation and how such responses evolve. Our research combines different approaches at the interface of developmental genetics, evolution and ecology.
Keywords: Gene-environment interactions, developmental plasticity, evolution of development
Braud Véronique/Anjuère Fabienne – Immune regulation at muco-cutaneous surfacesBraud Véronique/Anjuère Fabienne Immune regulation at muco-cutaneous surfaces
Our ongoing research aims to understand the fine tune dialog between both the epithelium and the tissue-associated innate immune cells during inflammation and skin carcinoma development. This understanding is critical for the development of rationale immunotherapeutic approaches.
Keywords: Carcinomas, epithelium, immunity, dendritic cells, natural killer cells.
Chaboissier Marie-Christine – Genetics of sex determination and fertilityChaboissier Marie-Christine Genetics of sex determination and fertility
Sex determination depends on a fine tuned balance between the SRY/SOX9 pathway, which precipitates testis differentiation, and the R-spondin/beta-catenin signaling pathway involved in ovarian differentiation. Our aim is to understand how these pathways regulate sexual differentiation in normal and pathological conditions.
Keywords: Sex determination, germ cells, R-spondin, Sox, signaling
Collombat Patrick – Diabetes GeneticsCollombat Patrick Diabetes Genetics
Our laboratory focuses on type 1 diabetes and, more particularly, on finding ways to induce the regeneration of pancreatic insulin-producing beta-cells using different transgenic mouse models.
Keywords: Diabetes, Regeneration, Insulin, Endocrine pancreas, Glucagon
Cristofari Gaël – Retrotransposon and genome plasticityCristofari Gaël Retrotransposon and genome plasticity
Retrotransposons are mobile genetic elements and represent half of our genome. Their mobility can drive profound genome rearrangements, which occasionally results in genetic diseases or cancer. We combine biochemistry, molecular and cellular biology and genomics to understand how the activity of these « jumping genes » is controlled and what is their impact on human health.
Keywords: Retrotransposon, LINE-1, Reverse Transcriptase, Next-Generation Sequencing, Cancer
Dani Christian – Stem cells and differentiationDani Christian Stem cells and differentiation
We do study factors regulating differentiation of human adipose-derived stem cells (hMADS cells) into white and brown adipocytes. We have also differentiated human induced Pluripotent Stem cells into adipocytes as a novel model to investigate the embryonic origins of human adipocytes and the earliest steps of their generation.
Key words: Adipocytes, Differentiation, adipose-derived stem cells, human induced pluripotent stem cells.
Delaunay Franck – Circadian System BiologyDelaunay Franck Circadian System Biology
Our group studies the role of circadian clocks in mammals. This research is focused on the interactions between clock genes and the molecular networks regulating two essential biological processes: energy metabolism and the cell cycle.
Keywords: Circadian clocks, metabolism, cell cycle, system biology
Descombes Xavier – Computational Morphometry and Morphodynamic of Cellular & Supracellular Structures (MORPHEME team : Inria/iBV/I3S)Descombes Xavier Computational Morphometry and Morphodynamic of Cellular &
Supracellular Structures (MORPHEME team : Inria/iBV/I3S)
The scientific objectives of MORPHEME are to characterize and model the development and the morphological properties of biological structures from the cell to the supra-cellular scale. Being at the interface between computational science and biology, we plan to understand the morphological changes that occur during development combining in vivo imaging, image processing and computational modeling.
Keywords: Image processing, computational biology, morphology, development, modeling
Feral Chloé – Epithelial homeostasis and tumorigenesisFeral Chloé Epithelial homeostasis and tumorigenesis
Our work aims at determining how the interactions of CD98, a dual function protein, which modulate integrin signaling and participate in amino acid transport, contribute to epidermal homeostasis and tumorigenesis. To do so, we use both murine conditional KO and cellular models.
Keywords: integrins, CD98, skin cancer, signaling, amino acid transport
Frendo Pierre – Nitrogen-fixing symbiosis and redox stateFrendo Pierre Nitrogen-fixing symbiosis and redox state
The team analyses the specific role of regulatory molecules of redox state in signalling, gene regulation and redox metabolism during nitrogen-fixing symbiosis. The molecular players involved in senescence of symbiosis are also investigated.
Keywords: Plants, nitrogen-fixing symbiosis, redox state, legumes, rhizobia.
Fürthauer Maximilian – Membrane dynamics and cell signaling in animal developmentFürthauer Maximilian Membrane dynamics and cell signaling in animal development
Through our work at the interface of cellular and developmental biology we study how the activity of membrane-bound signalling molecules is regulated by 1, the localization of signalling molecules in the cell and 2, the dynamic remodelling of cellular membranes in the course of animal development.
Key words: Endocytosis, Cilia, Exovesicles, Delta/Notch signalling, Zebrafish
Gilson Eric – Telomere, senescence and cancer
Gilson Eric Telomere, senescence and cancer
Our general aim is to increase our understanding of the basic mechanisms governing telomere functions and to explore their relevance in cancer and aging.
Keywords: Telomere, cellular senescence, cancer, chromatin, aging
Glaichenhaus Nicolas – Immunology and immune toleranceGlaichenhaus Nicolas Immunology and immune tolerance
We are broadly interested in immunology and more specifically in the interactions between the neural and immune system.
Keywords : Immunology, T lymphocytes, innate immunity, adaptive immunity
Gouzé Jean-Luc – Biological Control of artificial ecosystems (BIOCORE team: INRIA/INRA/CNRS/UPMC)Gouzé Jean-Luc Biological Control of artificial ecosystems (BIOCORE team: INRIA/INRA/CNRS/UPMC)
We build and study dynamical models of biological systems: intracellular models (of genetic and/or metabolic type,…), models of populations or at the scale of the ecosystems. Our tools are dynamical systems and control theory.
Keywords: Biological models Control Bioreactor Bioenergy Biosystems Ecosystems
Tran Albert/Gual Philippe – Hepatic complications in obesityTran Albert/Gual Philippe Hepatic complications in obesity
Hepatic complications in obesity (from fatty liver to hepatocellular carcinoma) is one of the most common forms of chronic liver diseases. Our main objectives are to better understand the molecular mechanisms leading to the progression of liver complications and also to develop a non-invasive index allowing the diagnosis of hepatic inflammation
Keywords: Obesity, Liver complications, NAFLD, human, Mice
Hofman Paul – Carcinogenesis related chronic active inflammationHofman Paul Carcinogenesis related chronic active inflammation
This team focuses its basic research on the cross talk between the microenvironment (mainly the neutrophils) and the cancer cells in order to understand the polarization of protumoral or antitumoral neutrophils during the initiation, the progression and the dissemination of cancer. A more translational research project includes the development of new targeted therapies for lung cancer.
Keywords: Cancer, neutrophils, tumor associated neutrophils, lung cancer, microRNA
Hueber Anne-Odile – Death receptors signaling and cancer therapyHueber Anne-Odile Death receptors signaling and cancer therapy
How the plasticity of death receptor signalling is controlled is a significant aspect in the balance of life and death decision of the cell, and a clear insight in the understanding of cancer biology. We focus our interest on finding out what directs Fas signalling to death or to tumorigenic non-death pathway to understand colorectal cancer initiation and progression.
Key words: death and survival signaling, colorectal cancer, membrane receptors dynamics, transport & sorting mechanisms, live cell imaging.
Lalli Enzo – Regulatory mechanisms of gene expression in physiopathologyLalli Enzo Regulatory mechanisms of gene expression in physiopathology
Our team investigates the mechanisms of gene expression regulation, with a special interest in the development, function and pathology of the adrenal cortex, using in an integrated fashion cellular and animal models together with genomic and pharmacological tools
Keywords: Gene expression, transcription factors, nuclear receptors, endocrinology, cancer
Lambeau Gérard – Molecular physiopathology of phospholipases A2 and their mediatorsLambeau Gérard Molecular physiopathology of phospholipases A2 and their mediators
Our team works on phospholipases A2, an emerging family of enzymes that hydrolyze phospholipids. Our current challenge is to identify their biological functions in physiological and disease conditions including reproduction, inflammation, atherosclerosis, cancer and a rare human kidney disease.
Keywords: Phospholipase A2, lipid mediators, inflammation, human diseases, therapeutic targets.
Lemichez Emmanuel – Microbial Toxins in host-pathogen interactionsLemichez Emmanuel Microbial Toxins in host-pathogen interactions
Our aim is to decipher the mode of action of bacterial toxins and their cellular targets by conducting cell biology and molecular biology approaches. This encompasses i) Rac1 GTPase regulation by ubiquitin-mediated proteasomal degradation and ii) induction of large transendothelial cell tunnels.
Keywords: Toxins, Pathogenic bacteria, endothelium, small GTPases, actin cytoskeleton
Leopold Pierre – Genetics and Physiology of growth in DrosophilaLeopold Pierre Genetics and Physiology of growth in Drosophila
Animal growth is linked to the developmental program in order to form an adult of species-specific size and proportions. We study the various environmental and developmental checkpoints and tissue crosstalks leading to the determination of final adult size and body proportions. We use Drosophila as a model and tackle these mechanisms using an array of genetic, cell and molecular biology tools.
Keywords: development, growth, insulin/IGF, genetics, Drosophila
Liti Gianni – Population genomics and complex traitsLiti Gianni Population genomics and complex traits
In our lab, we use the budding yeast, S. cerevisiae, to dissect the genetic architecture of multiple traits related to ageing and cancer. In all aspects of our research, we exploit natural variation in the budding yeast as a tool for understanding how a phenotype is genetically regulated.
Keywords: yeast, forward genetics, genome analysis, ageing, experimental evolution
Luton Frédéric/Franco Michel – Arf proteins, cell morphology and membrane transporLuton Frédéric/Franco Michel Arf proteins, cell morphology and membrane transpor
The plasma membrane is a dynamic structure whose coordinated remodeling with the associated cortical actin cytoskeleton is required for numerous biological functions. Our studies focus on the roles of the small G proteins of the Arf family in membrane trafficking and epithelial polarity.
Keywords: Small G proteins, membrane trafficking, actin cytoskeleton, epithelial polarity, breast cancer
Magnaldo Thierry/Meneguzzi Guerrino – Genetics and physiopathology of epithelial cancersMagnaldo Thierry/Meneguzzi Guerrino Genetics and physiopathology of epithelial cancers
Using cells from human skin of patients suffering from genetic condidtions prone to cancer as a system model, we study the content and mechanisms of action underlying interactions between stroma and cancer cells that favor tumor growth and dissemination.
Keywords: cancer, micro environment, stem cell, DNA repair, invasion
Marie Hélène – Molecular mechanisms of neuronal plasticity in health and diseaseMarie Hélène Molecular mechanisms of neuronal plasticity in health and disease
We study the molecular mechanisms underlying memory formation and how these mechanisms become defective in Alzheimer’s disease by combining various techniques such as electrophysiology, biochemistry, in vivo viral mediate recombinant expression systems and behavior.
Keywords: neuroscience, brain, memory, Alzheimer’s disease, synapse
Martin Stéphane – Activity-dependent dynamics and roles of synaptic sumoylationMartin Stéphane Activity-dependent dynamics and roles of synaptic sumoylation
Our focus is on sumoylation, a key posttranslational modification for many proteins including some involved in brain disorders. Using biochemical and state-of-the-art imaging techniques we investigate the regulatory mechanisms of the sumoylation pathway and functionally characterize novel sumoylated proteins in neurons.
Keywords: SUMO, Synapse, Trafficking, Brain disorders, Neuron.
Nahon Jean-Louis – Genomics and Evolution in Neuroendocrinology (GENE)Nahon Jean-Louis Genomics and Evolution in Neuroendocrinology (GENE)
The central thema of our research is: functional characterization of interactions between “primate-specific” genes and “common” genes involved in development, cellular activity and survival of neuronal networks regulating neuroendocrine functions : the PMCHL gene family /MCH signaling paradigm.
Keywords: Evolution, Primate Genomes, Hypothalamus, Feeding behavior, melanin-concentrating hormone.
Noselli Stéphane – Epithelial morphogenesis and left-right asymmetry in DrosophilaNoselli Stéphane Epithelial morphogenesis and left-right asymmetry in Drosophila
We study the role of JNK signaling and cell reprogramming in epithelia morphogenesis during Dorsal Closure. Using Border Cell Migration, we analyze the molecular mechanisms controlling epithelial-mesenchymal transition and cell invasion in vivo. We recently identified the genetic basis of left-right asymmetry establishment in Drosophila, deciphering the role of Myosin ID and of new players.
Keywords: Development, Drosophila, dorsal closure, cell migration, left-right asymmetry
Panabières Franck – Plant oomycete interactionsPanabières Franck Plant oomycete interactions
The aim of the research group is to elucidate the molecular mechanisms, which govern pathogenic strategies of the oomycete, and which are responsible, in plants, for the success (susceptibility) or the failure (resistance) of the infection process.
Keywords: Oomycetes, molecular dialogue, susceptibility, resistance, virulence
Poirié Marylène – Evolution and Specificity of Multitrophic Interactions (ESIM)Poirié Marylène Evolution and Specificity of Multitrophic Interactions (ESIM)
ESIM aims at elucidating the interactions between insect hosts, their parasitoids, and if relevant their symbionts, from the genetic and physiological level to « omic » approaches. It notably focuses on the evolution of immune interactions involving venom components of parasitoids.
Keywords: Parasitoid wasps, Venom, Immunity, Evolution, Integrative biology
Rassoulzadegan Minoo – RNA-mediated epigenetic heredityRassoulzadegan Minoo RNA-mediated epigenetic heredity
Our discovery of a non-Mendelian mode of paternal heredity, based on transfer of epigenetic information by sperm RNAs was recently extended to the heredity of obesity and type II diabetes induced by unhealthy diet. Currents projects develop the molecular analysis of RNA-mediated epigenetic heredity.
Keywords: RNA, sperm, epigenetics, genetics, mouse
Ricci Jean Ehrland – Metabolic control of cell deathsRicci Jean Ehrland Metabolic control of cell deaths
Cancer cells are very diverse. However they are sharing a few commune features including escape from cell death and a particular metabolism (Warburg effect). We are studying how the metabolism can prevent cell deaths and if targeting it could improve chemotherapeutic treatments.
Keywords: Cancer, Metabolism, apoptosis, non-apoptotic death, pre-clinical models
Robichon Alain – Genome Plasticity and EnvironmentRobichon Alain Genome Plasticity and Environment
Insect models to understand the molecular mechanisms controlling phenotypic adaptation to the fluctuating environment. Role of epigenetic regulations and heritability of epigenetic marks.
Keywords: Insects , environment , adaptation, DNA methylation, heredity of epigenetic marks
Schedl Andreas – Molecular programs controlling development and tissue homeostasisSchedl Andreas Molecular programs controlling development and tissue homeostasis
Development and tissue repair are highly interrelated processes. In our research program we try to understand the transcriptional control underlying organ development, define stem/progenitor cells and determine the signaling pathways involved in tissue maintenance and repair.
Keywords: Kidney disease, mouse models, stem cells, b-catenin signalling, Wilms’ tumor
Studer Michèle – Genetics of mouse cortical developmentStuder Michèle Genetics of mouse cortical development
Our research aims to understand the cellular and molecular mechanisms underlying the areal and laminar organization of the mouse cerebral cortex and how functional cortical circuits are established during development. We combine mouse genetics, in vivo and in vitro gene manipulation and morphological characterization to dissect signalling pathways and molecular cascades involved in cortical cell-type specification.
Keywords: cerebral cortex, development, mouse genetics, cortical circuits, transcription factors
Tanti Jean-François/Cormont Mireille – Cellular and Molecular Pathophysiology of Obesity and DiabetesTanti Jean-François/Cormont Mireille Cellular and Molecular Pathophysiology of Obesity and Diabetes
Activity: Our research focuses on the understanding of the cellular and molecular mechanisms involved in the development of insulin resistance and adipose tissue dysfunction in obesity and type 2 diabetes. Our goal is to identify new therapeutic targets for the treatment of obesity-associated pathologies.
Keywords: Inflammation, senescence, hypoxia, miRNA, endosomal traffic, signaling
Tartare-Deckert Sophie – Microenvironment, signaling and CancerTartare-Deckert Sophie Microenvironment, signaling and Cancer
We study crosstalk between cancer cell and its stroma within the lymph node microenvironment in two tumor models, melanoma and lymphoma. We perform candidate gene and unbiased screen approaches for new mediators of therapeutic response and we explore pathways that enable melanoma to invade lymphatics and to execute the metastatic cascade.
Keywords: Cancer-Cell signaling- Molecular medecine-Mouse models
Thérond Pascal – Secretion and Signaling of Morphogens in Drosophila developmentThérond Pascal Secretion and Signaling of Morphogens in Drosophila development
Our projects are focused on the mechanisms that regulate morphogen movement and transduction during pattern formation in Drosophila. By developing novel in vivo life imaging analysis and genetic screen we determine how the morphogen distribution and signalling activity are controlled by intra and extra-cellular regulators.
Keywords: Animal Development, Morphogen, Hedgehog, Cell Biology, Life Imaging
Trabucchi Michele – Control of Gene ExpressionTrabucchi Michele Control of Gene Expression
Our group is studying the molecular mechanisms underlying the regulation of NON-CODING RNAs expression as well as their function during the inflammatory response in macrophages by using different experimental approaches, including mass-spectrometry, siRNAs screening, and high-throughput deep sequencing analyses.
Keywords: NON-CODING RNAs; gene expression control, macrophages, cancer, metabolic disorders
Van Obberghen Emmanuel – Ageing and diabetesVan Obberghen Emmanuel Ageing and diabetes
Our research efforts are on Aging and Diabetes. Our main focus is on the following investigations:
1) how metabolic disturbances are responsible for insulin resistance and beta cell failure, and how ischemic hearts repair ; 2) how epigenetic mechanisms contribute to the increased risk of diabetes in offsprings after unfavorable in utero conditions.
Keywords: diabetes, cardiovascular complications, epigenetics, microRNAs
Van Obberghen-Schilling Ellen – Adhesion Signaling and Regulation of Cell Plasticity in the Tumor MicroenvironmentVan Obberghen-Schilling Ellen Adhesion Signaling and Regulation of Cell Plasticity in the Tumor Microenvironment
Our research is focused on adhesion-based signaling in head and neck cancer and glioblastomas. Ongoing projects address i) the impact of tumor-stroma interactions on tumor angiogenesis and invasion and ii) mechanisms that regulate the stem-cell state of cancer-initiating cells.
Keywords: tumor microenvironment, adhesion, cancer-initiating cells, head and neck cancer, glioblastomas