• Abad Pierre – Plant nematode interactions

    Abad Pierre                       Plant nematode interactionsPlant-parasitic nematodes have evolved sophisticated strategies for exploiting plants. These pathogens induce the redifferentiation of plant cells into specialized multinucleate feeding sites. We develop an integrated approach combining plant pathology and plant biotechnology to identify key players involved in signalling pathways of host–parasite molecular dialogue, plant development and immunity.Keywords: Plant, Nematode, Interaction, Development, Immunity

 

  • Antonny Bruno – Dynamics of lipid membranes and protein coats

    Antonny Bruno                                Dynamics of lipid membranes and protein coats We study (1) protein coats, which deform membranes into transport vesicles; (2) molecular strings, which tether vesicles at the Golgi; and (3) lipid transporters, which change the membrane composition and hence contribute to the maturation of membrane-bound organelles.Key words: membrane traffic, liposomes, cell biology, biochemistry and biophysics

 

  • Arkowitz Robert – Polarized growth in yeast

    Arkowitz Robert              Polarized growth in yeastOur primary interest is how cells spatially and temporally regulate their growth. We are examining the mechanisms of polarized growth and cell morphogenesis in both S. cerevisiae and C. albicans, in particular investigating the roles of G-proteins and lipids in these processes.Key words:  Polarized growth, morphogenesis, G-protein, lipids, cell shape

 

  • Auberger Patrick – Cell Death, Differentiation, Inflammation and Cancer

    Auberger Patrick             Cell Death, Differentiation, Inflammation and CancerOur team investigates the deregulation in cell death processes and autophagy in hematopoietic malignancies. We are also developping new alternative therapeutic strategies to circumvent the resistance to conventionnal chemotherapies focusing our interest on leukemia, myelodysplastic syndromes and myeloma.Keywords: Autophagy, Cell Deaths, Hematopoietic Malignancies, Resistance to Chemotherapies, New Anti-cancerous Therapies

 

  • Ballotti Robert – Biology and pathology of melanocytic cells: from cutaneous pigmentation to melanomas

    Ballotti Robert                  Biology and pathology of melanocytic cells: from cutaneous pigmentation to melanomasThe work of our team is focused on the study of the molecular mechanisms involved in melanocyte differentiation and in melanoma development, with special emphasis on MITF, a transcription factor that controls the expression on numerous genes playing a crucial role in melanocyte and melanoma biology.Keywords: Pigmentation, Cancer, therapy, transcription, epigenetic

 

  • Barbry Pascal – Physiological Genomics of the Eukaryotes

    Barbry Pascal                    Physiological Genomics of the EukaryotesRegulatory RNAs in normal and physiopathological function of epithelial tissues. Their roles in respiratory diseases. Technological developments for multi-parametric measurements in different biological models.
    Keywords: Gene expression, high throughput sequencing, bioinformatics, epithelium, cancer

 

  • Bardoni Barbara – Physiopathology of intellectual disability

    Bardoni Barbara               Physiopathology of intellectual disability
    The purpose of our research is to understand the molecular function of the RNA-binding protein FMRP, whose altered expression is linked to Fragile X syndrome, the most common form of intellectual disability and autism, and FXTAS, a late-onset neurodegenerative disorder.
    Keywords: Intellectual disability, autism, neurodegeneration, RNA-binding protein, RNA metabolism

 

  • Besse Florence – Post-transcriptional control of axon growth and guidance in Drosophila

    Besse Florence                 Post-transcriptional control of axon growth and guidance in Drosophila
    Our group studies the post-transcriptional regulatory mechanisms underlying the response of growing axons to external guidance signals in vivo, in particular the role of intracellular mRNA transport. Various approaches (genetics, live-imaging, biochemistry, bioinformatics) are combined.
    Keywords: developmental cell biology, polarized axon growth, RNA transport, genetics, live-imaging

 

  • Braendle Christian – Gene-environment interactions in development and evolution

    Braendle Christian          Gene-environment interactions in development and evolution
    We use the nematode Caenorhabditis elegans as a study organism to better understand how development responds to environmental variation and how such responses evolve. Our research combines different approaches at the interface of developmental genetics, evolution and ecology.
    Keywords: Gene-environment interactions, developmental plasticity, evolution of development

 

  • Braud Véronique/Anjuère Fabienne – Immune regulation at muco-cutaneous surfaces

    Braud Véronique/Anjuère Fabienne     Immune regulation at muco-cutaneous surfaces
    Our ongoing research aims to understand the fine tune dialog between both the epithelium and the tissue-associated innate immune cells during inflammation and skin carcinoma development. This understanding is critical for the development of rationale immunotherapeutic approaches.
    Keywords: Carcinomas, epithelium, immunity, dendritic cells, natural killer cells.

 

  • Chaboissier Marie-Christine – Genetics of sex determination and fertility

    Chaboissier Marie-Christine                      Genetics of sex determination and fertility
    Sex determination depends on a fine tuned balance between the SRY/SOX9 pathway, which precipitates testis differentiation, and the R-spondin/beta-catenin signaling pathway involved in ovarian differentiation. Our aim is to understand how these pathways regulate sexual differentiation in normal and pathological conditions.
    Keywords: Sex determination, germ cells, R-spondin, Sox, signaling

 

  • Collombat Patrick – Diabetes Genetics

    Collombat Patrick            Diabetes Genetics
    Our laboratory focuses on type 1 diabetes and, more particularly, on finding ways to induce the regeneration of pancreatic insulin-producing beta-cells using different transgenic mouse models.
    Keywords: Diabetes, Regeneration, Insulin, Endocrine pancreas, Glucagon

 

  • Cristofari Gaël – Retrotransposon and genome plasticity

    Cristofari Gaël                  Retrotransposon and genome plasticity            
    Retrotransposons are mobile genetic elements and represent half of our genome. Their mobility can drive profound genome rearrangements, which occasionally results in genetic diseases or cancer. We combine biochemistry, molecular and cellular biology and genomics to understand how the activity of these « jumping genes » is controlled and what is their impact on human health.
    Keywords: Retrotransposon, LINE-1, Reverse Transcriptase, Next-Generation Sequencing, Cancer

 

  • Dani Christian – Stem cells and differentiation

    Dani Christian                   Stem cells and differentiation
    We do study factors regulating differentiation of human adipose-derived stem cells (hMADS cells) into white and brown adipocytes. We have also differentiated human induced Pluripotent Stem cells into adipocytes as a novel model to investigate the embryonic origins of human adipocytes and the earliest steps of their generation.
    Key words: Adipocytes, Differentiation, adipose-derived stem cells, human induced pluripotent stem cells.

 

  • Delaunay Franck – Circadian System Biology

    Delaunay Franck              Circadian System Biology
    Our group studies the role of circadian clocks in mammals. This research is focused on the interactions between clock genes and the molecular networks regulating two essential biological processes: energy metabolism and the cell cycle.
    Keywords: Circadian clocks, metabolism, cell cycle, system biology

 

  • Descombes Xavier – Computational Morphometry and Morphodynamic of Cellular & Supracellular Structures (MORPHEME team : Inria/iBV/I3S)

    Descombes Xavier          Computational Morphometry and Morphodynamic of Cellular &
    Supracellular Structures (MORPHEME team : Inria/iBV/I3S)
    The scientific objectives of MORPHEME are to characterize and model the development and the morphological properties of biological structures from the cell to the supra-cellular scale. Being at the interface between computational science and biology, we plan to understand the morphological changes that occur during development combining in vivo imaging, image processing and computational modeling.
    Keywords: Image processing, computational biology, morphology, development, modeling

 

  • Feral Chloé – Epithelial homeostasis and tumorigenesis

    Feral Chloé                        Epithelial homeostasis and tumorigenesis
    Our work aims at determining how the interactions of CD98, a dual function protein, which modulate integrin signaling and participate in amino acid transport, contribute to epidermal homeostasis and tumorigenesis. To do so, we use both murine conditional KO and cellular models.
    Keywords: integrins, CD98, skin cancer, signaling, amino acid transport

 

  • Frendo Pierre – Nitrogen-fixing symbiosis and redox state

    Frendo Pierre                   Nitrogen-fixing symbiosis and redox state
    The team analyses the specific role of regulatory molecules of redox state in signalling, gene regulation and redox metabolism during nitrogen-fixing symbiosis. The molecular players involved in senescence of symbiosis are also investigated.
    Keywords: Plants, nitrogen-fixing symbiosis, redox state, legumes, rhizobia.

 

  • Fürthauer Maximilian – Membrane dynamics and cell signaling in animal development

    Fürthauer Maximilian    Membrane dynamics and cell signaling in animal development
    Through our work at the interface of cellular and developmental biology we study how the activity of membrane-bound signalling molecules is regulated by 1, the localization of signalling molecules in the cell and  2, the dynamic remodelling of cellular membranes in the course of animal development.
    Key words: Endocytosis, Cilia, Exovesicles, Delta/Notch signalling, Zebrafish

 

  • Gilson Eric – Telomere, senescence and cancer

     
    Gilson Eric                          Telomere, senescence and cancer
    Our general aim is to increase our understanding of the basic mechanisms governing telomere functions and to explore their relevance in cancer and aging.
    Keywords: Telomere,  cellular senescence, cancer, chromatin, aging

 

  • Glaichenhaus Nicolas – Immunology and immune tolerance

    Glaichenhaus Nicolas    Immunology and immune tolerance
    We are broadly interested in immunology and more specifically in the interactions between the neural and immune system.
    Keywords : Immunology, T lymphocytes, innate immunity, adaptive immunity

 

  • Gouzé Jean-Luc – Biological Control of artificial ecosystems (BIOCORE team: INRIA/INRA/CNRS/UPMC)

    Gouzé Jean-Luc                               Biological Control of artificial ecosystems (BIOCORE team: INRIA/INRA/CNRS/UPMC)
    We build and study dynamical models of biological systems: intracellular models (of genetic and/or metabolic type,…), models of populations or at the scale of the ecosystems. Our tools are dynamical systems and control theory.
    Keywords: Biological models Control Bioreactor Bioenergy Biosystems Ecosystems

 

  • Tran Albert/Gual Philippe – Hepatic complications in obesity

    Tran Albert/Gual Philippe           Hepatic complications in obesity
    Hepatic complications in obesity (from fatty liver to hepatocellular carcinoma) is one of the most common forms of chronic liver diseases. Our main objectives are to better understand the molecular mechanisms leading to the progression of liver complications and also to develop a non-invasive index allowing the diagnosis of hepatic inflammation
    Keywords: Obesity, Liver complications, NAFLD, human, Mice

 

  • Hofman Paul – Carcinogenesis related chronic active inflammation

    Hofman Paul                     Carcinogenesis related chronic active inflammation   
    This team focuses its basic research on the cross talk between the microenvironment (mainly the neutrophils) and the cancer cells in order to understand the polarization of protumoral or antitumoral neutrophils during the initiation, the progression and the dissemination of cancer. A more translational research project includes the development of new targeted therapies for lung cancer.
    Keywords: Cancer, neutrophils, tumor associated neutrophils, lung cancer, microRNA

 

  • Hueber Anne-Odile – Death receptors signaling and cancer therapy

    Hueber Anne-Odile       Death receptors signaling and cancer therapy 
    How the plasticity of death receptor signalling is controlled is a significant aspect in the balance of life and death decision of the cell, and a clear insight in the understanding of cancer biology. We focus our interest on finding out what directs Fas signalling to death or to tumorigenic non-death pathway to understand colorectal cancer initiation and progression.
    Key words: death and survival signaling, colorectal cancer, membrane receptors dynamics, transport & sorting mechanisms, live cell imaging.

 

  • Lalli Enzo – Regulatory mechanisms of gene expression in physiopathology

    Lalli Enzo                             Regulatory mechanisms of gene expression in physiopathology
    Our team investigates the mechanisms of gene expression regulation, with a special  interest in the development, function and pathology of the adrenal cortex, using in an integrated fashion cellular and animal models together with genomic and pharmacological tools
    Keywords: Gene expression, transcription factors, nuclear receptors, endocrinology, cancer

 

  • Lambeau Gérard – Molecular physiopathology of phospholipases A2 and their mediators

    Lambeau Gérard             Molecular physiopathology of phospholipases A2 and their mediators
    Our team works on phospholipases A2, an emerging family of enzymes that hydrolyze phospholipids. Our current challenge is to identify their biological functions in physiological and disease conditions including reproduction, inflammation, atherosclerosis, cancer and a rare human kidney disease.
    Keywords: Phospholipase A2, lipid mediators, inflammation, human diseases, therapeutic targets.

 

  • Lemichez Emmanuel – Microbial Toxins in host-pathogen interactions

    Lemichez Emmanuel     Microbial Toxins in host-pathogen interactions             
    Our aim is to decipher the mode of action of bacterial toxins and their cellular targets by conducting cell biology and molecular biology approaches. This encompasses i) Rac1 GTPase regulation by ubiquitin-mediated proteasomal degradation and ii) induction of large transendothelial cell tunnels.
    Keywords: Toxins, Pathogenic bacteria, endothelium, small GTPases, actin cytoskeleton

 

  • Leopold Pierre – Genetics and Physiology of growth in Drosophila

    Leopold Pierre                  Genetics and Physiology of growth in Drosophila
    Animal growth is linked to the developmental program in order to form an adult of species-specific size and proportions. We study the various environmental and developmental checkpoints and tissue crosstalks leading to the determination of final adult size and body proportions. We use Drosophila as a model and tackle these mechanisms using an array of genetic, cell and molecular biology tools.
    Keywords: development, growth, insulin/IGF, genetics, Drosophila

 

  • Liti Gianni – Population genomics and complex traits

    Liti Gianni                            Population genomics and complex traits
    In our lab, we use the budding yeast, S. cerevisiae, to dissect the genetic architecture of multiple traits related to ageing and cancer. In all aspects of our research, we exploit natural variation in the budding yeast as a tool for understanding how a phenotype is genetically regulated.
    Keywords: yeast, forward genetics, genome analysis, ageing, experimental evolution

 

  • Luton Frédéric/Franco Michel – Arf proteins, cell morphology and membrane transpor

    Luton Frédéric/Franco Michel                   Arf proteins, cell morphology and membrane transpor             
    The plasma membrane is a dynamic structure whose coordinated remodeling with the associated cortical actin cytoskeleton is required for numerous biological functions. Our studies focus on the roles of the small G proteins of the Arf family in membrane trafficking and epithelial polarity.
    Keywords: Small G proteins, membrane trafficking, actin cytoskeleton, epithelial polarity, breast cancer

 

  • Magnaldo Thierry/Meneguzzi Guerrino – Genetics and physiopathology of epithelial cancers

    Magnaldo Thierry/Meneguzzi Guerrino                  Genetics and physiopathology of epithelial cancers
    Using cells from human skin of patients suffering from genetic condidtions prone to cancer as a system model, we study the content and mechanisms of action underlying  interactions between stroma and cancer cells that favor tumor growth and dissemination.
    Keywords: cancer, micro environment, stem cell, DNA repair, invasion

 

  • Marie Hélène – Molecular mechanisms of neuronal plasticity in health and disease

    Marie Hélène                   Molecular mechanisms of neuronal plasticity in health and disease
    We study the molecular mechanisms underlying memory formation and how these mechanisms become defective in Alzheimer’s disease by combining various techniques such as electrophysiology, biochemistry, in vivo viral mediate recombinant expression systems and behavior.
    Keywords: neuroscience, brain, memory, Alzheimer’s disease, synapse

 

  • Martin Stéphane – Activity-dependent dynamics and roles of synaptic sumoylation

    Martin Stéphane             Activity-dependent dynamics and roles of synaptic sumoylation         
    Our focus is on sumoylation, a key posttranslational modification for many proteins including some involved in brain disorders. Using biochemical and state-of-the-art imaging techniques we investigate the regulatory mechanisms of the sumoylation pathway and functionally characterize novel sumoylated proteins in neurons.
    Keywords: SUMO, Synapse, Trafficking, Brain disorders, Neuron.

 

  • Nahon Jean-Louis – Genomics and Evolution in Neuroendocrinology (GENE)

    Nahon Jean-Louis           Genomics and Evolution in Neuroendocrinology (GENE)          
    The central thema of our research is: functional characterization of interactions between “primate-specific” genes and “common” genes involved in development, cellular activity and survival of neuronal networks regulating neuroendocrine functions : the PMCHL gene family /MCH signaling paradigm.
    Keywords: Evolution, Primate Genomes, Hypothalamus, Feeding behavior, melanin-concentrating hormone.

 

  • Noselli Stéphane – Epithelial morphogenesis and left-right asymmetry in Drosophila

    Noselli Stéphane             Epithelial morphogenesis and left-right asymmetry in Drosophila
    We study the role of JNK signaling and cell reprogramming in epithelia morphogenesis during Dorsal Closure. Using Border Cell Migration, we analyze the molecular mechanisms controlling epithelial-mesenchymal transition and cell invasion in vivo. We recently identified the genetic basis of left-right asymmetry establishment in Drosophila, deciphering the role of Myosin ID and of new players.
    Keywords: Development, Drosophila, dorsal closure, cell migration, left-right asymmetry

 

  • Panabières Franck – Plant oomycete interactions

    Panabières Franck          Plant oomycete interactions
    The aim of the research group is to elucidate the molecular mechanisms, which govern pathogenic strategies of the oomycete, and which are responsible, in plants, for the success (susceptibility) or the failure (resistance) of the infection process.
    Keywords: Oomycetes, molecular dialogue, susceptibility, resistance, virulence

 

  • Poirié Marylène – Evolution and Specificity of Multitrophic Interactions (ESIM)

    Poirié Marylène               Evolution and Specificity of Multitrophic Interactions (ESIM)
    ESIM aims at elucidating the interactions between insect hosts, their parasitoids, and if relevant their symbionts, from the genetic and physiological level to « omic » approaches. It notably focuses on the evolution of immune interactions involving venom components of parasitoids.
    Keywords: Parasitoid wasps, Venom, Immunity, Evolution, Integrative biology

 

  • Rassoulzadegan Minoo – RNA-mediated epigenetic heredity

    Rassoulzadegan Minoo                RNA-mediated epigenetic heredity
    Our discovery of a non-Mendelian mode of paternal heredity, based on transfer of epigenetic information by sperm RNAs was recently extended to the heredity of obesity and type II diabetes induced by unhealthy diet. Currents projects develop the molecular analysis of RNA-mediated epigenetic heredity.
    Keywords: RNA, sperm, epigenetics, genetics, mouse

 

  • Ricci Jean Ehrland – Metabolic control of cell deaths

    Ricci Jean Ehrland            Metabolic control of cell deaths
    Cancer cells are very diverse. However they are sharing a few commune features including escape from cell death and a particular metabolism (Warburg effect). We are studying how the metabolism can prevent cell deaths and if targeting it could improve chemotherapeutic treatments.
    Keywords: Cancer, Metabolism, apoptosis, non-apoptotic death, pre-clinical models

 

  • Robichon Alain – Genome Plasticity and Environment

    Robichon Alain                 Genome Plasticity and Environment
    Insect models to understand the molecular mechanisms controlling phenotypic adaptation  to the fluctuating environment. Role of epigenetic regulations and heritability of epigenetic marks.
    Keywords: Insects , environment , adaptation, DNA methylation, heredity of epigenetic marks

 

  • Schedl Andreas – Molecular programs controlling development and tissue homeostasis

    Schedl Andreas                                Molecular programs controlling development and tissue homeostasis
    Development and tissue repair are highly interrelated processes. In our research program we try to understand the transcriptional control underlying organ development, define stem/progenitor cells and determine the signaling pathways involved in tissue maintenance and repair.
    Keywords: Kidney disease, mouse models, stem cells, b-catenin signalling, Wilms’ tumor

 

  • Studer Michèle – Genetics of mouse cortical development

    Studer Michèle                                Genetics of mouse cortical development
    Our research aims to understand the cellular and molecular mechanisms underlying the areal and laminar organization of the mouse cerebral cortex and how functional cortical circuits are established during development. We combine mouse genetics, in vivo and in vitro gene manipulation and morphological characterization to dissect signalling pathways and molecular cascades involved in cortical cell-type specification.
    Keywords: cerebral cortex, development, mouse genetics, cortical circuits, transcription factors

 

  • Tanti Jean-François/Cormont Mireille – Cellular and Molecular Pathophysiology of Obesity and Diabetes

    Tanti Jean-François/Cormont Mireille   Cellular and Molecular Pathophysiology of Obesity and Diabetes
    Activity: Our research focuses on the understanding of the cellular and molecular mechanisms involved in the development of insulin resistance and adipose tissue dysfunction in obesity and type 2 diabetes. Our goal is to identify new therapeutic targets for the treatment of obesity-associated pathologies.
    Keywords: Inflammation, senescence, hypoxia, miRNA, endosomal traffic, signaling

 

  • Tartare-Deckert Sophie – Microenvironment, signaling and Cancer

    Tartare-Deckert Sophie                               Microenvironment, signaling and Cancer
    We study crosstalk between cancer cell and its stroma within the lymph node microenvironment in two tumor models, melanoma and lymphoma. We perform candidate gene and unbiased screen approaches for new mediators of therapeutic response and we explore pathways that enable melanoma to invade lymphatics and to execute the metastatic cascade.
    Keywords: Cancer-Cell signaling- Molecular medecine-Mouse models

 

  • Thérond Pascal – Secretion and Signaling of Morphogens in Drosophila development

    Thérond Pascal                 Secretion and Signaling of Morphogens in Drosophila development
    Our projects are focused on the mechanisms that regulate morphogen movement and transduction during pattern formation in Drosophila. By developing novel in vivo life imaging analysis and genetic screen we determine how the morphogen distribution and signalling activity are controlled by intra and extra-cellular regulators.
    Keywords: Animal Development, Morphogen, Hedgehog, Cell Biology, Life Imaging

 

  • Trabucchi Michele – Control of Gene Expression

    Trabucchi Michele          Control of Gene Expression
    Our group is studying the molecular mechanisms underlying the regulation of NON-CODING RNAs expression as well as their function during the inflammatory response in macrophages by using different experimental approaches, including mass-spectrometry, siRNAs screening, and high-throughput deep sequencing analyses.
    Keywords: NON-CODING RNAs; gene expression control, macrophages, cancer, metabolic disorders

 

  • Van Obberghen Emmanuel – Ageing and diabetes

    Van Obberghen Emmanuel                       Ageing and diabetes
    Our  research efforts are on Aging and Diabetes. Our main focus is on the following investigations:
    1)  how metabolic disturbances are responsible for insulin resistance and beta cell failure, and how ischemic hearts repair ;  2) how epigenetic mechanisms contribute to the  increased risk of diabetes in offsprings  after unfavorable in utero conditions.
    Keywords: diabetes, cardiovascular complications, epigenetics, microRNAs

 

  • Van Obberghen-Schilling Ellen – Adhesion Signaling and Regulation of Cell Plasticity in the Tumor Microenvironment

    Van Obberghen-Schilling Ellen                  Adhesion Signaling and Regulation of Cell Plasticity in the Tumor Microenvironment
    Our research is focused on adhesion-based signaling in head and neck cancer and glioblastomas. Ongoing projects address i) the impact of tumor-stroma interactions on tumor angiogenesis and invasion and ii) mechanisms that regulate the stem-cell state of cancer-initiating cells.
    Keywords: tumor microenvironment, adhesion, cancer-initiating cells, head and neck cancer, glioblastomas

 

6 Partners

Institutions

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